Targeted co-delivery of paclitaxel and chrysin by hyaluronate/chitosan-coated polymeric nanoparticles for prostate cancer chemotherapy

IF 2.5 4区 医学 Q4 MATERIALS SCIENCE, BIOMATERIALS
Behzad Jamali, Sajjad Jamali, Sevil Vaghefi Moghaddam, Mohsen Firoozrai, Soodabeh Davaran, Fatemeh Abedi
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引用次数: 0

Abstract

AbstractChemotherapy is one of the most common therapeutic approaches in most cancers like prostate cancer, which has always faced limitations. The purpose of the present study was to design and prepare the targeted polymeric nanoparticles for the co-delivery of Paclitaxel (PTX) and Chrysin (CHR) to prostate cancer cells to improve the PTX therapeutic efficacy. Through the current research, the surface modification of the PTX/CHR-loaded PCL-PEG-PCL nanoparticles with chitosan and hyaluronic acid (PTX/CHR-PCEC-CS/HA) was successfully performed through the physical adsorption process. SEM results showed that this polymeric NPs had a homogeneous spherical structure. The encapsulation efficiency was 78.6 and 93.28% for CHR and PTX, respectively. It is important to mention that the controlled drug-release behavior of the PTX/CHR-PCEC-CS/HA was also investigated. The results demonstrated that the dual drug-loaded PCEC-CS/HA NPs had a significant effect on reducing the survival of the cancer. Also, the results exhibited that the cytotoxicity of the dual drug-loaded polymeric NPs in the PC3 cell line is significantly higher than in the HUVEC cell line. Based on the findings, the targeted PTX/CHR-PCEC-CS/HA NPs could be employed as a suitable candidate for the effective treatment of the prostate cancer.Keywords: paclitaxelChrysinpolymeric nanoparticlesprostate cancertargeted drug delivery AcknowledgmentsThis project was fulfilled at the Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran. We would like to thank the Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran for their assistance in this research. Besides, the authors would like to thank the Drug Applied Research Center, Tabriz University of Medical Sciences cooperation in this project.Author contributionsAll authors have given approval to the final version of the manuscript.Disclosure statementNo potential conflict of interest was reported by the author(s).Data availability statementNo data was used for the research described in the article.
透明质酸/壳聚糖包被的聚合纳米颗粒靶向递送紫杉醇和金菊素用于前列腺癌化疗
摘要化疗是前列腺癌等大多数癌症最常用的治疗方法之一,但一直面临着局限性。本研究的目的是设计和制备靶向聚合纳米颗粒,用于紫杉醇(PTX)和Chrysin (CHR)共同递送前列腺癌细胞,以提高PTX的治疗效果。通过本研究,壳聚糖和透明质酸通过物理吸附工艺成功地对PTX/ cr - pcec - cs /HA负载的PCL-PEG-PCL纳米颗粒进行了表面改性。SEM结果表明,该聚合物NPs具有均匀的球形结构。CHR和PTX的包封率分别为78.6和93.28%。值得一提的是,我们还研究了PTX/ chrc - pcec - cs /HA的控释行为。结果表明,双载PCEC-CS/HA NPs具有显著的降低肿瘤生存期的作用。结果表明,双载药聚合NPs在PC3细胞系中的细胞毒性明显高于在HUVEC细胞系中的细胞毒性。基于这些发现,靶向PTX/ chrc - pcec - cs /HA NPs可以作为有效治疗前列腺癌的合适候选物。关键词:紫杉醇金聚合物纳米颗粒前列腺癌靶向给药项目由伊朗大不里士医科大学药学院完成。我们要感谢伊朗大不里士医科大学大不里士药学院对这项研究的协助。同时感谢大不里士医科大学药物应用研究中心对本项目的合作。作者的贡献所有作者都对手稿的最终版本给予了认可。披露声明作者未报告潜在的利益冲突。数据可用性声明本文所描述的研究未使用任何数据。
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来源期刊
International Journal of Polymeric Materials and Polymeric Biomaterials
International Journal of Polymeric Materials and Polymeric Biomaterials Chemical Engineering-General Chemical Engineering
CiteScore
8.00
自引率
3.10%
发文量
97
审稿时长
3.3 months
期刊介绍: International Journal of Polymeric Materials and Polymeric Biomaterials is the official publication of the International Society for Biomedical Polymers and Polymeric Biomaterials (ISBPPB). This journal provides a forum for the publication of peer-reviewed, English language articles and select reviews on all aspects of polymeric materials and biomedical polymers. Being interdisciplinary in nature, this journal publishes extensive contributions in the areas of encapsulation and controlled release technologies to address innovation needs as well.
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