Antihypertensive Effect of Milk Fermented by Lactiplantibacillus plantarum K79 on Spontaneously Hypertensive Rats

IF 4.2 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Science of Animal Resources Pub Date : 2023-11-14 DOI:10.5851/kosfa.2023.e70

Sang-Dong Lim, Kyungwon Lee, Taewon Han, Hyunjhung Jhun, Ah-Ram Han, Yongjin Hwang, Sangpil Hong

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Abstract

The aim of this study is to investigate whether milk fermented by Lactiplantibacillus plantarum K79, which exhibits ACE inhibitory activity, has an effect on lowering the blood pressure of hypertensive rats and to investigate biomarker changes in their blood. Experimental group: normal group (NG, WKY): distilled water, control group (NCG, SHR): distilled water, high treatment group (HTG, SHR): 500 mg/kg/day, medium treatment group (MTG, SHR): 335 mg/kg/day, low treatment group (LTG, SHR): 170 mg/kg/day, positive control group(PCG, SHR): Enalapril, 10 mg/kg/day. The experimental animals used in this study were divided into groups composed of 8 animals. In terms of weight change, a significant difference was observed between the normal group and the SHR group, but there was no significant difference between the SHR group. After 8 weeks of feeding, Blood pressure was lowered more significantly in the HTG(209.9±13.3 mmHg) than in the NCG(230.8±7.3 mmHg). The treatment group has an effect of lowering blood pressure by significantly suppressing blood pressure-related biomarker protein expression than NG. The results obtained can be used as an antihypertensive material in a variety of food raw materials.

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植物乳杆菌K79发酵乳对自发性高血压大鼠的降压作用

本研究旨在探讨具有ACE抑制活性的植物乳杆菌K79发酵乳是否具有降低高血压大鼠血压的作用，并探讨高血压大鼠血液中生物标志物的变化。实验组:正常组(NG、WKY):蒸馏水，对照组(NCG、SHR):蒸馏水，高处理组(HTG、SHR): 500 mg/kg/天，中处理组(MTG、SHR): 335 mg/kg/天，低处理组(LTG、SHR): 170 mg/kg/天，阳性对照组(PCG、SHR):依那普利，10 mg/kg/天。本研究使用的实验动物每组8只。在体重变化方面，正常组与SHR组有显著差异，而SHR组之间无显著差异。喂养8周后，HTG组血压(209.9±13.3 mmHg)明显低于NCG组(230.8±7.3 mmHg)。治疗组与NG相比，显著抑制血压相关生物标志物蛋白表达，具有降低血压的作用。所得结果可作为多种食品原料中的降压物质。

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来源期刊

Food Science of Animal Resources Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

6.70

自引率

6.70%

发文量

期刊介绍： Food Science of Animal Resources (Food Sci. Anim. Resour.) is an international, peer-reviewed journal publishing original research and review articles on scientific and technological aspects of chemistry, biotechnology, processing, engineering, and microbiology of meat, egg, dairy, and edible insect/worm products.