Management of Casualties from Radiation Events

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Robert Alan Dent
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引用次数: 0

Abstract

Radiation events such as nuclear war, nuclear reactor incidents, and the deployment of a radioactive dispersal device (dirty bomb) are all significant threats in today’s world. Each of these events would bring significant challenges to clinicians caring for patients with burns and traumatic injuries who are also contaminated or irradiated. The result of a nuclear exchange in a densely populated area could result in thousands of patients presenting with trauma, burns, and combined injury (trauma and burn in an irradiated patient). In this review, we will discuss the three major types of ionizing radiation: alpha, beta, and gamma, and their respective health hazards and biological effects. Additionally, we will discuss the types of burn injuries in a nuclear disaster, caring for the contaminated patient, and managing the combined injury of burn trauma with acute radiation syndrome. The reader will also be left with an understanding of how to prioritize lifesaving interventions, estimate the absorbed dose of radiation, and predict the onset of acute radiation syndrome. While some animal models for morbidity and mortality exist, there is limited modern day human data for patients with combined injury and burns associated with a nuclear disaster due to the infrequent nature of these events. It is extremely important to continue multidisciplinary research on the prevention of, preparedness for, and the response to nuclear events. Furthermore, continued exploration of novel treatments for radiation induced burns and the management of combined injury is necessary.
辐射事故伤亡管理
核战争、核反应堆事故和放射性扩散装置(脏弹)的部署等辐射事件都是当今世界的重大威胁。这些事件中的每一个都将给护理烧伤和创伤性损伤患者的临床医生带来重大挑战,这些患者也受到污染或辐照。在人口稠密地区进行核交换的结果可能导致数千名患者出现创伤、烧伤和复合损伤(受辐射患者出现创伤和烧伤)。在这篇综述中,我们将讨论三种主要类型的电离辐射:α、β和γ,以及它们各自的健康危害和生物效应。此外,我们将讨论核灾难中烧伤的类型,受污染患者的护理,以及烧伤创伤合并急性辐射综合征的处理。读者也将留下如何优先考虑挽救生命的干预措施的理解,估计辐射的吸收剂量,并预测急性辐射综合征的发作。虽然存在一些发病率和死亡率的动物模型,但由于这些事件的罕见性,与核灾难相关的复合损伤和烧伤患者的现代人类数据有限。在核事件的预防、准备和反应方面继续开展多学科研究是极其重要的。此外,继续探索放射性烧伤的新治疗方法和复合损伤的处理是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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