Indicators of reproduction when using complex use of drugs for spontaneous manifestation of heat in cows for mycotoxicosis

Abstract

Alimentary infertility is becoming increasingly important due to the toxic effects of mycotoxins, especially zearalenone and deoxynivalenol, which leads to a decrease in the efficiency of the cattle breeding industry, so it is necessary to examine this problem. The purpose of the study was to identify the effect of the complex use of sorbents, acidifiers, and aromatase inhibitors on the reproductive capacity of cows in mycotoxicosis. During the study, clinical methods (general examination) and biochemical methods (serum content of calcium, magnesium, urea, total and direct bilirubin, malonic dialaldehyde, aminotransferase activity) were used. Cows were divided into two groups: the first group was a control group, where no treatment was used, and cows of the second group received a comprehensive treatment method. A decrease in the level of calcium to 1.68±0.53 mmol/L, phosphorus – 0.98±0.16, selenium – 0.64±0.1 mmol/L, an increase in the level of magnesium to 1.15±0.17 mmol/L, an increase in aspartate aminotransferase to 121.33±3.91 units, alataminotransferase to 79.31±6.53 units, and total bilirubin to 10.21±0.55 mmol/l, malone aldehyde up to 8.27±0.41 mmol/L, and ceruloplasmin up to mmol/L 2.14±0.39 in chronic mycotoxicosis caused by zearalenone and deoxynivalenol. When using a complex treatment regimen for animals, a substantial change and approximation to the reference levels of selenium, creatinine, AST, ALT, malonic aldehyde, and ceruloplasmin were established. The use of the proposed treatment regimen increases the fertilising capacity of cows after the 1st calving by 18.15%, cows aged 3-4 years – 30.12%, and cows of the older age group – by 40.47%. A complex method of treatment of cows for mycotoxicosis caused by zearalenone is proposed using an acidifier based on organic acids, a sorbent based on celeolite and an aromatase inhibitor, which can be used in livestock farms for the production of milk and meat of various forms of ownership to restore and normalise the reproductive ability of cows