A Machine Learning-Based Classification of Immunogenic Cell Death Regulators and Characterisation of Immune Microenvironment in Acute Ischemic Stroke

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2023-11-14 DOI:10.1155/2023/9930172

Mengying Wang, Guolian Wei, Shaorui Gu, Zhengyuan Huo, Xue Han

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引用次数: 0

Abstract

Immunogenic cell death (ICD) regulators exert a crucial part in quite a few in numerous biological processes. This study aimed to determine the function and diagnostic value of ICD regulators in acute ischemic stroke (AIS). 31 significant ICD regulators were identified from the gene expression omnibus (GEO) database in this work (the combination of the GSE16561 dataset and the GSE37587 dataset in the comparison of non-AIS and AIS patients). The random forest model was applied and 15 potential ICD regulators were screened to forecast the probability of AIS. A nomogram, on the basis of 11 latent ICD regulators, was performed. The resolution curve analysis indicated that patients can gain benefits from the nomogram. The consensus clustering approach was applied, and AIS patients were divided into 2 ICD clusters (cluster A and cluster B) based on the identified key ICD regulatory factors. To quantify the ICD pattern, 181 ICD-related dissimilarly expressed genes (DEGs) were selected for further investigation. The expression levels of NFKB1, NFKB2, and PARP1 were greater in gene cluster A than in gene cluster B. In conclusion, ICD regulators exerted a crucial part in the progress of AIS. The investigation made by us on ICD patterns perhaps informs prospective immunotherapeutic methods for AIS.

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急性缺血性卒中中基于机器学习的免疫原性细胞死亡调节因子分类和免疫微环境表征

免疫原性细胞死亡(ICD)调控因子在许多生物过程中发挥着重要作用。本研究旨在探讨ICD调节因子在急性缺血性脑卒中(AIS)中的功能及诊断价值。在这项工作中，从基因表达综合数据库(GSE16561数据集和GSE37587数据集的组合，用于非AIS和AIS患者的比较)中鉴定出31个重要的ICD调控因子。应用随机森林模型，筛选15个潜在的ICD调节因子来预测AIS的概率。在11个潜在ICD调节因子的基础上，进行了nomogram。分辨率曲线分析表明，患者可以从图中获益。采用共识聚类方法，根据确定的关键ICD调节因子将AIS患者分为2个ICD类(A类和B类)。为了量化ICD模式，选择181个与ICD相关的不相似表达基因(DEGs)进行进一步研究。NFKB1、NFKB2和PARP1在A基因簇中的表达水平高于b基因簇。可见，ICD调控因子在AIS的进展中起着至关重要的作用。我们对ICD模式的研究可能会为AIS的前瞻性免疫治疗方法提供信息。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.

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