Magnetic surface molecularly imprinted polymers for efficient selective recognition and targeted separation of daidzein

IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2023-10-25 DOI:10.1007/s42114-023-00775-5

Biao Wang, Yi Kuang, Minghui Li, Xing Wang, Xiaotian Zhang, Qingqing Rao, Bingnan Yuan, Shengxiang Yang

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Abstract

Daidzein, a naturally occurring source of estrogenic isoflavones, holds significant promise for various applications in food and drug development. Therefore, to realize efficient and precise daidzein separation, we synthesized a magnetic surface molecularly imprinted polymer (Daidzein/SMIPs) via free radical-initiated polymerization via magnetic surface molecular imprinting technology. The adsorption capacity of the Daidzein/SMIPs for daidzein at an initial concentration of 300 µg·mL⁻¹ reached 18.44 mg·g⁻¹ within 20 min at 298 K. Even after nine adsorption-desorption cycles, the adsorption capacity remained high (81.42% of the initial adsorption capacity). Furthermore, the Daidzein/SMIPs exhibited exceptional selectivity for daidzein, with an imprinting factor of 1.83 and selection coefficients (K) of 1.94, 2.43, 2.63, and 1.66 for structurally similar competing molecules such as naringin, quercetin, diosmetin, and alizarin, respectively. In practical applications, isolating daidzein from real daidzein tablets using the Daidzein/SMIPs resulted in high recoveries of 88.09 to 98.12% with excellent precision (relative standard deviation of 1.51–1.02%). Therefore, the constructed Daidzein/SMIPs feature immense potential for targeted daidzein isolation applications.

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磁性表面分子印迹聚合物对大豆苷元的高效选择性识别和靶向分离

大豆苷元是一种天然存在的雌激素异黄酮来源，在食品和药物开发中的各种应用具有重要的前景。因此，为了实现大豆苷元高效、精确的分离，我们利用磁性表面分子印迹技术，通过自由基引发聚合合成磁性表面分子印迹聚合物(daidzein /SMIPs)。在298 K条件下，初始浓度为300µg·mL−1时，smip对大豆苷元的吸附量在20 min内达到18.44 mg·g−1。即使经过9次吸附-解吸循环，吸附容量仍然很高(为初始吸附容量的81.42%)。此外，大豆苷元/ smip对结构相似的竞争分子(柚皮素、槲皮素、薯蓣皂苷和茜素)的印迹因子为1.83，选择系数(K)分别为1.94、2.43、2.63和1.66。在实际应用中，采用该方法从大豆苷元片中分离出大豆苷元，回收率为88.09 ~ 98.12%，精密度为1.51 ~ 1.02%。因此，构建的大豆苷元/ smip具有靶向大豆苷元分离应用的巨大潜力。

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.