Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications.

IF 3.6 3区医学 Q3 CELL & TISSUE ENGINEERING

World journal of stem cells Pub Date : 2023-10-26 DOI:10.4252/wjsc.v15.i10.960

Wen-Bo Xing, Shu-Ting Wu, Xin-Xin Wang, Fen-Yao Li, Ruo-Xuan Wang, Ji-Hui He, Jiao Fu, Yan He

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引用次数: 0

Abstract

Peripheral nerve injury (PNI) seriously affects people's quality of life. Stem cell therapy is considered a promising new option for the clinical treatment of PNI. Dental stem cells, particularly dental pulp stem cells (DPSCs), are adult pluripotent stem cells derived from the neuroectoderm. DPSCs have significant potential in the field of neural tissue engineering due to their numerous advantages, such as easy isolation, multidifferentiation potential, low immunogenicity, and low transplant rejection rate. DPSCs are extensively used in tissue engineering and regenerative medicine, including for the treatment of sciatic nerve injury, facial nerve injury, spinal cord injury, and other neurodegenerative diseases. This article reviews research related to DPSCs and their advantages in treating PNI, aiming to summarize the therapeutic potential of DPSCs for PNI and the underlying mechanisms and providing valuable guidance and a foundation for future research.

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牙髓干细胞及其制品促进周围神经再生的潜力及其应用前景。

周围神经损伤严重影响人们的生活质量。干细胞治疗被认为是临床治疗PNI的一个有希望的新选择。牙髓干细胞，特别是牙髓干细胞是来源于神经外胚层的成体多能干细胞。DPSCs具有易于分离、具有多向分化潜力、免疫原性低、移植排斥率低等优点，在神经组织工程领域具有重要的应用前景。DPSCs广泛应用于组织工程和再生医学，包括治疗坐骨神经损伤、面神经损伤、脊髓损伤和其他神经退行性疾病。本文就DPSCs治疗PNI的相关研究及其优势进行综述，旨在总结DPSCs治疗PNI的潜力及其作用机制，为今后的研究提供有价值的指导和基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of stem cells Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

7.80

自引率

4.90%

发文量

750

期刊介绍： The World Journal of Stem Cells (WJSC) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of stem cells. It was launched on December 31, 2009 and is published monthly (12 issues annually) by BPG, the world''s leading professional clinical medical journal publishing company.