DISTRIBUTION OF MYCOBACTERIUM AVIUM COMPLEX IN BULGARIA

PROBLEMS of Infectious and Parasitic Diseases Pub Date : 2018-12-27 DOI:10.58395/pipd.v46i2.18

Y. Atanasova, S. Yordanova, Y. Todorova, A. Baikova, E. Bachiyska

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引用次数: 1

Abstract

The members of Mycobacterium avium complex (MAC) are opportunistic microorganisms, common in the environment (soil and water) and cause infections in birds, mammals and humans. The objective of the present study was to determine the prevalence of MAC representatives among suspected for tuberculosis patients in Bulgaria over an eight-year period – from 2010 to 2017. The exact epidemiology of pulmonary non-tuberculous mycobacterial (NTM) disease was difficult to determine because unlike cases of infection with M. tuberculosis complex, notification of NTM and MAC in particular, is not mandatory in terms of Ordinance 21 of the Ministry of Health (1) and there is no any accurate information about their prevalence in Bulgaria. The survey was conducted in the National Reference Laboratory of Tuberculosis at the National Centre of Infectious and Parasitic Diseases. MAC was identified using phenotypic methods, biochemical features and molecular genetic assay (LPA). A total of 596 NTM strains were identified during the study period and 16.8% (n=100) of them were MAC. In EU countries, MAC representatives areprevalent among NTM isolates, but in Bulgaria they are significantly less in number.

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禽分枝杆菌复合体在保加利亚的分布

禽分枝杆菌复合体(MAC)的成员是机会性微生物，在环境(土壤和水)中很常见，并引起鸟类、哺乳动物和人类的感染。本研究的目的是确定保加利亚8年期间(2010年至2017年)疑似结核病患者中MAC代表的患病率。很难确定肺非结核分枝杆菌病的确切流行病学，因为与结核分枝杆菌复合感染病例不同，根据卫生部第21号法令(1)，通报非结核分枝杆菌病和结核分枝杆菌病并不是强制性的，而且没有关于它们在保加利亚流行情况的任何准确信息。这项调查是在国家传染病和寄生虫病中心的国家结核病参考实验室进行的。采用表型方法、生化特征和分子遗传分析(LPA)对MAC进行鉴定。在研究期间共鉴定出596株NTM菌株，其中16.8% (n=100)为MAC。在欧盟国家，MAC代表在NTM分离株中普遍存在，但在保加利亚，它们的数量明显较少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PROBLEMS of Infectious and Parasitic Diseases

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