EXTRACEREBELLAR SIGNS OF SPINOCEREBELLAR ATAXIA TYPE 5

Abstract

Background: The vast majority of studies and reviews state that spinocerebellar ataxia type 5 (SCA5) is exclusively manifested by pure ataxia. We found scant information on extracerebellar manifestations of SCA5. Objective: The purpose of our review was to find any information about extracerebellar signs of spinocerebellar ataxia type 5. Methods: PubMed and Google Scholar resources were used to write the review article. Results: Ranum L.P., et al. (1994), and Bürk K., et al. (2004) described writer’s cramp dystonia, facial myokymia, limited lateral gaze, brisk reflexes, and impaired vibration sense in patients with SCA5 [1, 2]. Maschke M., et al. (2005) noticed the possible presence of hyperreflexia, incontinence, tingling and cramps, diplopia, horizontal and vertical ophthalmoparesis in patients with SCA5 [3]. Spagnoli C., et al. (2020) documented infantile-onset SCA5 with optic atrophy and peripheral neuropathy, and bilateral cataracts as associated findings [4]. Stevanin G., et al. (1999) had shown that facial myokymia and decreased vibration sense are frequent and reflect lesions of other structures than the cerebellum or its pathways [5]. We did not find any article describing parkinsonism in patients with SCA5. Conclusion: Extracerebellar manifestations of SCA5 are rare, but at the same time they can occur and are described in the literature.