Efektifitas Penyembuhan Luka Sayat Spray Gel Minyak Nilam Pada Kelinci (Oryctolagus cuniculus)

Abstract

Patchouli plant (Pogostemon cablin Benth) produces essential oilplants containing sesquiterpenes and patchouli alcohol compounds that function as anti-inflammatory. In addition, patchouli oil also contains terpenoid compounds that have antibacterial and antifungal activity. This study aims to determine the effect of wound healing in patchouli oil spray gel on rabbits. The spray gel formulation used in this study was to add the active substance of pure patchouli oil with concentrations of 5%, 7.5%, and 10%. The resulting spray gel formulation was tested on rabbit cuts with six treatments, namely positive control (bioplacenton), negative control (base), control without treatment, patchouli oil spray gel with concentrations of 5%, 7.5%, and 10%. The test was carried out for 14 days, giving the ointment two times a day (every 12 hours) with three replication. The analysis was carried out by calculating the average percentage of wound healing time and analyzed using the one-way ANOVA test. The results of the three formulations of patchouli oil spray gel showed that the preparation with a concentration of 10% had no significantly different results (P>0.05) compared to the positive control. Statistical results on the three spray gel formulation showed that there was a significant difference (p < 0.05) between the treatment groups. It can be said that the spray gel preparation at a concentration of 5% was significantly different from the preparation with a concentration of 10%. Where increasing the concentration of patchouli oil will accelerate the percentage of wound healing on the rabbit's back.