The prognostic role of neutrophil/lymphocyte ratio and monocyte/lymphocyte ratio in advanced stage gastric cancer patients receiving chemotherapy: a single center experience

Interdisciplinary Medical Journal Pub Date : 2023-08-10 DOI:10.17944/interdiscip.1351892

Kubilay Karaboyun, E. Şeber

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Abstract

Objective: Several studies revealed that peripheral blood Neutrophil/Lymphocyte ratio (NLR) and Monocyte/Lymphocyte Ratio (MLR) were prognostic in various cancer types. However, there are no excessive information about the prognostic significance of NLR and MLR in patients with advanced gastric cancer. As a result, we examined whether NLR and/or MLR could be used as a prognostic marker to predict survival outcomes in patients with advanced gastric cancer receiving palliative chemotherapy. Method: We retrospectively analyzed 119 patients with gastric cancer receiving chemotherapy. We evaluated the relationship between potential prognostic factors and overall survival (OS) times using the Kaplan-Meier method and Cox regression survival modelling. Results: The median overall survival of the patients was 6.9 (2.1-41.6) months. In univariate analysis, NLR (p< 0.001), ECOG performance status (p< 0.001), presence of liver metastases (p< 0.001) and presence of peritoneal metastases (p< 0.001) were found to be associated with survival. The multivariate survival model showed the high NLR (HR=1.59, 95% CI 1.6-2.40, p= 0.026), the patients with ECOG performance score 2-3 (HR=2.91, 95% CI 1.60-5.27, p

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中性粒细胞/淋巴细胞比率和单核细胞/淋巴细胞比率在晚期胃癌化疗患者预后中的作用:单中心经验

目的:多项研究表明，外周血中性粒细胞/淋巴细胞比值(NLR)和单核细胞/淋巴细胞比值(MLR)对不同类型肿瘤的预后有重要影响。然而，关于NLR和MLR在晚期胃癌患者的预后意义，目前还没有过多的信息。因此，我们研究了NLR和/或MLR是否可以作为预后指标来预测接受姑息性化疗的晚期胃癌患者的生存结果。方法:对119例接受化疗的胃癌患者进行回顾性分析。我们使用Kaplan-Meier方法和Cox回归生存模型评估潜在预后因素与总生存(OS)时间之间的关系。结果:患者的中位总生存期为6.9(2.1-41.6)个月。在单因素分析中，NLR (p< 0.001)、ECOG表现状态(p< 0.001)、肝转移(p< 0.001)和腹膜转移(p< 0.001)的存在与生存率相关。多因素生存模型显示，高NLR (HR=1.59, 95% CI 1.6 ~ 2.40, p= 0.026)， ECOG表现评分为2 ~ 3分的患者(HR=2.91, 95% CI 1.60 ~ 5.27, p= 0.026)

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Interdisciplinary Medical Journal

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