Antagonists of the Mineralocorticoid Receptor or A New Pharmacological Class

Abstract

A reduction in the blood pressure levels triggers, among other responses, a signaling cascade mainly controlled by the kidneys; this event is responsible for reestablishing the blood pressure, being known as renin, angiotensin, and aldosterone system – RAAS. The aldosterone, the last hormone released in this cascade, displays several effects in its target tissue such as kidneys, colon, brain, and cardiovascular system [1]; however, high levels of aldosterone, in certain diseases, lead to deleterious effects in most of these organs. In the next lines, our focus will be the on the cardiac tissue.