Analysis of Biogenic Amines Exchange in Dystonia

Abstract

Dystonia – is the debilitating movement disorder of central nervous system often inherited, appearing as involuntary movements, which occur due to deficiency or excess of neurotransmitters, mainly biogenic amines, such as dopamine, noradrenalin, and serotonin. The exact cause has been unveiled only in few forms of dystonia, such as dopa – responsive dystonia, where dopamine deficiency has been established, while the cause of most others forms of dystonia remaining obscure. Numerous studies of these forms have detected neurotransmitters disturbance, but those reports are very contradictory. In present study we explore the latent factors unifying some biogenic amines together into clusters bearing common certain functional mission in norm and in pathologic states such as dystonia. We compare the results obtained in dystonia group and in control of group of patients observed for suspicion for neuroglial tumors and we established that latent factors, unifying groups of biogenic amines, differ between the D group and the control group. We also have compared these two groups by means of discriminative analysis and As a result of discriminate analysis we derived equations of canonical linear discriminate (classification) functions (LCF) that probably can detect or exclude dystonia at examination of latent forms or “formes frustes” of this disorder. We expect to get even much more evident result by recruiting healthy control and by widening the spectre of biogenic amines measured.