Renal hypertension in rats with hereditary polycystic kidney disease.

Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01

J Kaspareit-Rittinghausen, F Deerberg, K G Rapp, A Wcislo

引用次数: 0

Abstract

Hereditary polycystic kidney disease (PKD) was observed in a Han:SPRD rat mutant. Cysts were of tubular origin and occurrence was more pronounced in males than in females. In male rats polycystic kidney disease was associated with a marked elevation of systolic blood pressure. Therefore this rat mutant can be considered as a laboratory animal model for renal hypertension associated with adult polycystic kidney disease in man.

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遗传性多囊肾病大鼠肾性高血压的研究。

在汉族:SPRD大鼠突变体中观察到遗传性多囊肾病(PKD)。囊肿为管状起源，男性比女性更明显。在雄性大鼠中，多囊肾病与收缩压的显著升高有关。因此，该大鼠突变体可作为成人多囊肾病相关肾性高血压的实验动物模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zeitschrift fur Versuchstierkunde

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