[Effect of indomethacin on the vital prognosis and homeostasis of rats with kidney insufficiency].

Abstract

The medicamentous-therapeutic modulation of pathogenic hyperfiltration of residual nephrons by the prostaglandin synthesis inhibitor indomethacin was evaluated again. The experimental study of inbred wistar rats including a low indomethacin dosage of 1.5 mg/kg BW, a strong reduction of renal parenchyma (80%) and an increased food protein content of 40% did show the known results: indomethacin may impair the vital prognosis of severe renal injury.