Role of tumor-associated Macrophages in Tumor Development

Abstract

The role of tumor-associated macrophages (TAM) in tumor development cannot be ignored. The number of Tams is related to the malignant degree of tumors and poor prognosis. Tams with obvious heterogeneity and plasticity are the main components of solid tumor microenvironment and become a promising target for cancer immunotherapy. Targeted therapy for TAM, combined with traditional treatment methods, may bring a new dawn to the treatment of tumors. This review summarizes the origin, types, roles in tumor progression and treatment strategies of Tams, aiming to provide new ideas and methods for the research and treatment of Tams.