Synergistic Effect of Irradiated Sodium Alginate and Methyl Jasmonate on Anticancer Alkaloids Production in Periwinkle (Catharanthus roseus L.)

F. Rasheed, M. Naeem, M. Uddin, M. M. Khan
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引用次数: 1

Abstract

Periwinkle (Catharanthus roseus L.) G. Don contains about 130 indole terpenoid alkaloids including vincristine and vinblastine, which are antineoplastic drugs produced in a very minute quantity in periwinkle leaves. Researchers have been finding ways to enhance the production of these valuable alkaloids. A pot experiment was conducted on periwinkle to explore the effect of single and combined application of irradiated sodium alginate (ISA) and methyl jasmonate (MeJA) on growth, physiological attributes and alkaloids production (vincristine and vinblastine) at 6 and 9 month after plantation (MAP). Foliar application of ISA at 80 mg L−1 improved the growth and other physiological parameters, whereas MeJA at 40 mg L−1 enhanced the content and yield of anticancer alkaloids (vincristine and vinblastine). As compared with the control, their combined application (80 mg L−1 of ISA and 40 mg L−1 of MeJA) increased the total alkaloids content by 33.8 and 36.6% and the total alkaloids yield by 47.7 and 58.0% at 6 and 9 MAP, respectively. Combined application increased the vincristine content by 46.7 and 42.8% and vincristine yield by 59.8 and 66.0% at 6 and 9 MAP, respectively. Similarly, it increased the vinblastine content by 24.6 and 21.0% and the vinblastine yield by 35.3 and 40% at 6 and 9 MAP, respectively. Conclusively, combined application of ISA and MeJA could be considered recommendable to enhance the anticancer alkaloids of periwinkle.
辐照海藻酸钠和茉莉酸甲酯对长春花抗癌生物碱合成的协同效应
长春花(Catharanthus roseus)G. Don含有约130种吲哚萜类生物碱,包括长春新碱和长春碱,它们是长春花叶子中极少量产生的抗肿瘤药物。研究人员一直在寻找提高这些有价值的生物碱产量的方法。以长春花为材料,通过盆栽试验,探讨了在种植后6个月和9个月单独和联合施用辐照海藻酸钠(ISA)和茉莉酸甲酯(MeJA)对长春花生长、生理特性和生物碱(长春新碱和长春新碱)产量的影响。叶面施用80 mg L−1的ISA促进了植株的生长和其他生理参数,而40 mg L−1的MeJA提高了抗癌生物碱(长春新碱和长春花碱)的含量和产量。与对照相比,在6 MAP和9 MAP条件下,ISA 80mg L−1和MeJA 40mg L−1联合施用,总生物碱含量分别提高了33.8%和36.6%,总生物碱产量分别提高了47.7%和58.0%。在6和9 MAP条件下,联合施用长春新碱含量分别提高46.7%和42.8%,长春新碱产量分别提高59.8%和66.0%。同样,在6和9 MAP处理下,长春碱含量分别提高24.6%和21.0%,长春碱产量分别提高35.3%和40%。综上所述,ISA和MeJA联合应用可提高长春花的抗癌生物碱含量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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