Responsive Nanoparticles for Triggered Delivery of Anti-scar Drug to the Burn Wound

Abstract

The importance of developing anti-scar wound dressing comes from the fact that scar as an abnormal tissue affects aesthetics and changes the functionality of tissue strength and pliability[1]. The main group of patients who are at risk of scar formation is burn survivors. The World Health Organization (WHO) reports that annually 11 million people suffer from severe burn wounds that need medical care [2]–[6]. Burn scar has devastating effects, including pain, intolerance of heat, severe itching, limitations in movement, and dyspigmentation; these factors lead to problems with social integration [7] and discrimination in the community [8] which can reduce the burn survivors' quality of life. Commonly available treatments for scar prevention or reduction, such as stem cell therapy or surgical approaches, are limited in reaching a satisfying result. These limits drive the need for advanced progress in the field of drug delivery. Numerous studies have been published on developing anti-scar wound dressings; nevertheless, a clinical product has not been produced yet.