[The sodium excretion behavior of anesthetized and conscious spontaneously-hypertensive (SHR) and normotensive (WKY) rats].

Abstract

Urethane-anesthetized and conscious, immobilized SHR subjected to osmotic diuresis, responded to intravenous saline loading with a larger natriuresis than WKY-rats due to an increased urine sodium concentration without differences in urine flow. Blood pressure and heart rate reactions after saline loading were qualitatively different in anesthetized and conscious rats. The magnitude of these changes was larger in WKY than in SHR in both experimental groups.