[The role bronchial circulation in the etiopathogenesis of increased bronchial reactivity].

Abstract

The relationship between pathoanatomical changes in bronchial arteries and occurrence of chronic obstructive bronchitis (COB) and bronchial asthma (BA) was studied. Pathoanatomical changes in bronchial arteries were more frequently found in patients with COB and BA than in patients with other bronchopulmonary diseases, i.e. that bronchial circulation in patients with COB and BA is impaired. Due to these findings a theory of vasculary-metabolic explanation of pathogenesis of bronchial hyperresponsiveness is based on hypoperfusion and hypoxia of cellular structures in the bronchial wall. Hypoxia is supposed to be an endogenous change in the bronchial wall which causes bronchial hyperresponsiveness in various exogenous stimulants.