Subcellular near-field biomolecule sampling using a biosensor

Abstract

As the initial experiments towards integrating the near-field ablation and a fiber-optic biosensor, we report the near-field ablation on Arabidopsis thaliana leaf samples with a 2μm ablation spot. We also report time-dependent spectral plots of detecting biomolecules in the ground Arabidopsis leaf solution. The sensitivity of detecting biomolecules with amino functional groups was improved by using a biosensor coated with a specific type of cross linkers.