[Sleep-related breathing disorders in adults: diagnosis, consequences and comorbidities].

Abstract

Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a collapse of the upper airways leading to a decrease (hypopneas) or interruption of air flow (apneas). Since its identification, only forty years ago, definitions, diagnostic techniques have evolved, the consequences of this syndrome have been widely studied but establishing it as an independent cardiovascular (CV) risk factor has come up against the existence of many confounding factors, such as obesity, high blood pressure (hypertension)… Paraclinical diagnosis is based on the results of poly(somno)graphy. Recommendations on measurement techniques and scoring are regularly published, evolving in parallel with technological progress, with the aim of standardizing and ensuring the reliability of the diagnosis. At the same time, large cohort studies were set up in the 1990s, allowing for transversal and longitudinal follow-up of thousands of patients. Finally, the pathophysiological mechanisms of the consequences of SAHOS were explored. OSA has been shown to be responsible for a particularly high accidental risk due to sleep fragmentation induced by abnormal respiratory events. It has been possible to establish an independent statistical relationship between SAHOS and CV diseases, metabolic disorders and more recently cancer, mainly explained by intermittent hypoxia. OSAHOS is a frequent disease, diagnosed on the basis of clinical signs and poly(somno)graphy, now established as an independent risk factor for morbidity and mortality (accidental and CV).