Decitabine-Induced Posterior Reversible Encephalopathy Syndrome in a Patient with Myelodysplastic Syndrome

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder characterized by its reversibility both radiologically and clinically, and it typically has a favorable prognosis. Its etio-pathogenesis is not clear, although it is known that it involves endothelial dysfunction of the posterior cerebral vasculature, leading to failed cerebral autoregulation. We report a patient with PRES that may have been caused by an immune-mediated response to decitabine.