The covalent attachment of Naltrexone to multi-walled carbon nanotubes byoxalyl chloride agent

Abstract

This work presents a novel cascade of chemical functionalization of multi-walled carbon nanotubes(MWCNTs) through chemical modification by an opioid antagonist drug of Naltrexone. Naltrexone-conjugated MWCNTs were synthesized involving the sequential steps of carboxylation, acylation,and finally,Naltrexoneconjugation.The active acyl chlorides in MWCNTs were subsequently mixed with opioid antagonist drug of Naltrexone.The modification of MWCNTs with Naltrexone was investigated by Fourier transform-infrared spectroscopy,Raman spectroscopy,Thermo Gravimetric Analysis,Elemental Analysis,High Performance Liquid Chromatography.Size and surface characteristics of chemically modified MWCNTs were monitored by Transmission Electron Microscopy,Scanning Electron Microscopy,Field Emission Scanning Electron Microscopy,Atomic Force Microscopy.