Adoption and validation of the international normalized ratio for monitoring oral anticoagulant therapy: the situation in 1989.

A M van den Besselaar
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引用次数: 1

Abstract

The INR/ISI system has been validated in multicenter trials. The system provides a reliable scale for the intensity of oral anticoagulation. It has been recognized that the ISI is slightly dependent on the instrument used for prothrombin time determination. External quality assessment (EQA) of the INR in national programs should be stimulated. EQA results suggest that the precision of the INR can be improved. Many physicians prescribing coumarin congeners are not familiar with the INR system. Improvement of the situation can only be achieved by continuous education.

国际标准化比例监测口服抗凝治疗的采用与验证:1989年的情况。
INR/ISI系统已在多中心试验中得到验证。该系统为口服抗凝剂的强度提供了可靠的尺度。人们已经认识到,ISI稍微依赖于用于凝血酶原时间测定的仪器。应鼓励在国家项目中开展INR外部质量评估(EQA)。EQA结果表明,该方法可以提高INR的精度。许多开香豆素同类药物处方的医生并不熟悉INR系统。这种状况的改善只能通过继续教育来实现。
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