A review of the Pathogenesis and Pathology of Bovine Schistosomosis

C. Bila, D. Silva, E. Gruys
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Abstract

Keywords: Schistosomosis, zoonosis, cattle, pathology, pathogenesis Schistosomes are trematodes of separate sex living in blood vessels. They have part of their life cycle in a snail before becoming cercariae, and they reach the final host. Schistosomosis is a zoonosis. Several aspects of schistosomosis and Schistosoma species, their geographical distribution, life cycle, mode of infection, control and treatment are reviewed. The comparative pathogenesis and pathology of the disease in bovine, man and other species with regard to parasite species and organs of the host involved, are presented and discussed. The clinical features and pathological changes result more from the eggs than from the adult parasites themselves. The eggs release soluble antigen that is captured and presented by antigen presenting cells (APCs). The APCs stimulate CD4 + T cells through costimulator molecules. The CD4 + T cells secrete cytokines leading to granulomatous reaction and fibrosis. These are major changes associated with clinical disorders. Around the eggs club-like eosinophilic protein deposits, the so-called Splendore-Hoeppli phenomenon, can form. Questions for further veterinary investigations are addressed. Trop. Vet. Vol. 20(4) 2002: 181-196
牛血吸虫病的发病机制和病理研究进展
关键词:血吸虫病,人畜共患病,牛,病理,发病机制。在成为尾蚴之前,它们在蜗牛体内有一部分生命周期,然后到达最终的宿主。血吸虫病是一种人畜共患病。综述了血吸虫病和血吸虫种类、地理分布、生命周期、感染方式、控制和治疗的几个方面。比较发病机制和病理的牛,人和其他物种的寄生虫种类和有关的宿主器官,提出和讨论。临床特征和病理变化更多是由虫卵引起的,而不是由成虫本身引起的。卵释放出可溶性抗原,被抗原提呈细胞(APCs)捕获并呈递。apc通过共刺激分子刺激CD4 + T细胞。CD4 + T细胞分泌细胞因子导致肉芽肿反应和纤维化。这些是与临床疾病相关的主要变化。在卵子周围会形成棒状的嗜酸性蛋白沉积,即所谓的Splendore-Hoeppli现象。讨论了进一步兽医调查的问题。太。兽医。Vol. 20(4) 2002: 181-196
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