Biochemical Changes of Dexamethasone on Liver and Kidney Functions in Laboratory Mice Mus musculus L.

Abstract

Background: The present study sought to verify the effect of dexamethasone on the biochemical changes in different organs, such as liver and kidney organs of both sexes, male and female mice. Materials & Method: Muc muscular males and female mice (n=48) were used. To determine the effects of dexamethasone on the biochemical changes of liver and kidney organs, mice received a low dose (2mg/kg) and a high dose (4 mg/kg) of dexamethasone continuously for one month. Result: The results showed a significant increase (P<0.05) in Liver enzymes (ALP, AST, ALT). The urea and creatinine levels also increased in the treated mice and both sexes with the pesticide compared with the control group. Keywords: mice, histological, liver, kidney, dexamethasone, toxicity