FORMULATION AND EVALUATION OF ORAL SOLUTION FOR RHEUMATOID ARTHRITIS

Abstract

Background: Arthritis is becoming more prevalent with time in Pakistan. An autoimmune and inflammatory condition, rheumatoid arthritis mostly affects the joints. Since most immune suppressants are injectable, it was very difficult for patients to follow their treatment regimen on a daily basis. Aims: To develop a liquid dosage form with minimal adverse drug reactions (ADRs) associated with immuno-suppressants. Methodology: For this purpose, a combination of aloe vera with anti-inflammatory effects and prednisolone with immunosuppressant effects is used. Firstly, aloe vera extract was taken and blended with distilled water, sweetened with sucralose and added in prednisolone solution along with other excipients. The results of efficacy, density, viscosity and specific gravity were as within ranges. Result: There is no discoloration and cloudiness. The results of efficacy, density, viscosity and specific gravity were as within ranges. Conclusion: Aloe juice has synergistic effects as an anti-inflammatory agent. This combination lessened the ADRs associated with prednisolone, however it doesn’t compromise the therapeutic effects.