Histopathological and immunohistochemical studies on the effects of Ethephon on liver and kidney in male rats

Abstract

Ethephon can release ethylene which could affect the plant growth process. The current study was designed to study the possible toxic effects of ethephon on both liver and kidneys of male rats. 20 adult male rats were divided into 2 groups; the first group is control and the second group received Ethephon at dose (200 mg/kg body weight/day) for four weeks. At the end of the study liver and kidney tissues were taken and examined histopathologically. Ethephon administration to rats showed marked injury in liver and kidney. Also, liver and kidney sections in treated rats with Ethephon showed strong positive affinity for PCNA expressions. These results indicated that Ethephon could be harmful on liver and kidney. Producers and consumers should become more aware about the toxic effects of Ethephon.