Immunohistochemical location of S-100 and glial fibrillary acidic proteins in salivary gland pleomorphic adenomas.

Abstract

The S-100 protein is a low molecular weight protein which has been isolated mainly in mammalian brain cells. Glial fibrillary acidic protein is one of the five types of intermediate filaments described to date. We used immunohistochemical methods to study the expression in this patterns of expression of these two proteins in pleomorphic adenoma of the salivary glands, in an attempt to explain their tumor and to elucidate the origin of this complex neoplasm of the salivary glands.