BIOASSAY FOR THE CHOLEKINETICS IN DOMESTIC PIG

Abstract

Bioassay for the cholekinetics was established with the domestic pigs, separating into the effects of the contraction of the gallbladder and of the rela xation of the sphincter of Oddi. The contraction of the gallbladder was estimated with Magnus method. The potency of the relaxation of the sphincter of Oddi was estimated by the relaxation of the common bile-duct and by the number of drops through the sphincter before and after the administration of drug. According to this method of assay described above, it was demonstrated that MgSO4, pilocarpine, peptone, papaverine and desoxycholate gave rise to the relaxation of the sphincter of Oddi, but atropine had almost no response.