Carbon Nanomaterials as a Potential Agents for Induction of Apoptosis In Cancerous Tissue

Y. Lahir
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Abstract

Cancerous condition is the result of abnormal physiological and cellular mechanisms that develop in an individual. The cells prone to cancer exhibit complexed behavioral abnormalities and disobedience to the normal cellular signaling pathways. Benign and malignant cancers show different proliferative behavior depending on the type of cells, their location, and functions. The cancerous tissues have increased vascular supply and a lower ratio of the rate of conversion of oxy-hemoglobin to deoxy-hemoglobin. In tissues, like the dense radiographic breast, show some morphological changes in the cell organelles like nuclei. The carbon nanoparticles act as suitable agents for carrying antiviral drugs, antibiotics, anticancer drugs, agents for imaging, and thermal ablation. Further, considering the multifaceted features, carbon nanomaterials can be a potential agent to induce apoptosis in the cancerous tissue that might help to restrict its growth. All these intentions need careful examinations, applications at laboratory, clinical, and mass-scale production, keeping in mind the environmental, judicial aspects, and human tendencies of maximizing their benefits. This short review is an effort to evaluate the potentials of carbon nanomaterials that can induce apoptosis in cancer tissue.
碳纳米材料作为诱导癌组织凋亡的潜在药物
癌症是个体发生的异常生理和细胞机制的结果。易患癌症的细胞表现出复杂的行为异常和对正常细胞信号通路的不服从。良性和恶性肿瘤根据细胞类型、位置和功能的不同表现出不同的增殖行为。癌组织血管供应增加,氧血红蛋白转化为脱氧血红蛋白的比率降低。在组织中,如致密乳腺x线摄影,显示细胞器如细胞核的一些形态学改变。碳纳米颗粒作为携带抗病毒药物、抗生素、抗癌药物、成像剂和热消融剂的合适试剂。此外,考虑到碳纳米材料的多面性,碳纳米材料可能是一种潜在的诱导癌组织凋亡的药物,可能有助于限制其生长。所有这些意图都需要仔细检查,在实验室、临床和大规模生产中应用,同时要牢记环境、司法方面以及人类最大化其利益的倾向。这篇简短的综述是为了评估碳纳米材料在癌症组织中诱导细胞凋亡的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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