{"title":"Study on enhancement of tumor-killing effect and formation of new fluorophore in tumor cells.","authors":"X J Fan, E H Cao, S J Chi, Y X Wang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Hyperthermia (42-44 degrees C) and photosensitizing therapy can destroy S180 tumor cells, reduce malignant ascites and prolong the survival times of mice with carcinomas. The highest curative effect was observed when using a combination of the two treatments. Heating to 44 degrees C has a greater destructive effect on tumor cells than has heating to 42 degrees C. The results show that this is due to a synergistic interaction between these two treatments. The fluorescence spectrum of S180 cells was determined before and after treatment, and the indication was that the synergistic effect is probably related to a new fluorescence product; the greater the intensity of the new fluorescence, the more marked the synergy of hyperthermia and photosensitizing therapy. The maximum emission wavelength was 460nm (excitation wavelength 370nm).</p>","PeriodicalId":77596,"journal":{"name":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","volume":"5 2","pages":"107-11"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Hyperthermia (42-44 degrees C) and photosensitizing therapy can destroy S180 tumor cells, reduce malignant ascites and prolong the survival times of mice with carcinomas. The highest curative effect was observed when using a combination of the two treatments. Heating to 44 degrees C has a greater destructive effect on tumor cells than has heating to 42 degrees C. The results show that this is due to a synergistic interaction between these two treatments. The fluorescence spectrum of S180 cells was determined before and after treatment, and the indication was that the synergistic effect is probably related to a new fluorescence product; the greater the intensity of the new fluorescence, the more marked the synergy of hyperthermia and photosensitizing therapy. The maximum emission wavelength was 460nm (excitation wavelength 370nm).
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