[Metabolism of 14C-labeled urea in conventional and bacteria-free guinea pigs].

Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01

N C Juhr, J Franke

引用次数: 0

Abstract

This report deals with the utilization of 14C-labeled urea in antibiotically decontaminated, bacteria-free guinea pigs using intragastric resp. intraperitoneal administration route. With conventional animals 52% of the intragastrically administered 14C dose can be demonstrated in the exhaled air, 1.2% in organs and 41% in the urine. 1.8% were found in intestinal and faecal contents. In bacteria-free animals 29% of the activity appeared in the exhaled air, 52% in urine and 2% remain in the intestinal tract, feces and animal body. Intraperitoneal administration of 14C urea revealed 17% resp. 14% in the exhaled air, 72% resp. 66% in urine and 2% resp. 3% in intestinal tract, feces and animal body in conventional resp. bacteria-free guinea pigs.

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[常规豚鼠和无菌豚鼠体内14c标记尿素的代谢]。

本报告探讨了14c标记尿素在经抗生素消毒、无细菌的豚鼠胃内排泄中的应用。腹腔给药途径。在常规动物中，经胃给药的14C剂量有52%在呼出的空气中，1.2%在器官中，41%在尿液中。在肠道和粪便内容物中发现1.8%。在无细菌的动物中，29%的活性出现在呼出的空气中，52%出现在尿液中，2%留在肠道、粪便和动物体内。腹腔注射14C尿素，有效率为17%。呼出空气中占14%，呼吸中占72%。尿液中66%，血液中2%。在肠道、粪便和动物体内的含量为3%。无菌豚鼠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zeitschrift fur Versuchstierkunde

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