A novel theranostics nanoparticles pGGA-PTX / SPION with bifunction of diagnosis and treatment

Abstract

To increase the solubility of free drugs, drug-loaded efficiency and prolong the half-life of drugs in the body, a novel theranostics nano-particles, pGGA-PTX / SPION with a good diagnosis and treatment function have been fabricated. It is plump and uniform in size, to 113.0 ± 0.6nm, leading to the passive targeting of tumor tissue due to the EPR effect. The content-loaded of PTX was about 27.66%. The contrast agent content was about 6.34%. In vitro evaluation such as cell viability, the pGGA-PTX / SPION NPs were similar to that of PTX, suggesting a useful anticancer effect on tumor cells. In the H&E experiment, the pGGA-PTX / SPION did not impair the normal tissue and fully proved its safety performance. In vivo imaging, the pGGA-PTX / SPION in the tumor body can clearly be observed by NMR, to achieve real-time monitoring of drugs. In vivo treatment effects experiment, the pGGA-PTX / SPION exhibits a significant tumor growth inhibition effect.