Mucocutaneous Adverse Drug Reactions In A Hospital Setting In Cameroon

Abstract

Mucocutaneous drug reactions are common in our setting. Our objectives were to evaluate the prevalence of mucocutaneous drug reactions due to systemic drugs. A retrospective cohort study of outpatients with the diagnosis of Adverse Drug Reaction was carried out over 6 years in the University Teaching Hospital, Yaoundé. 138 cases of mucocutaneous drug reactions were evaluated. Fixed Drug Eruptions accounted for more than 60.7% of all the Adverse Drug Reactions. Sulphonamides were responsible for 82% of all the Fixed Drug Eruptions and were the offending drug in 65% of all the Adverse Drug Reactions documented. 28.9% of the subjects were HIV positive. 24 cases were hospitalized because of severity out of which 6 died (25%).The prevalence of drug reactions in the study is 3.5 %. The most common drug reaction is the Fixed Drug Eruption. The most offending drugs are Sulphonamides. Proper management of Adverse Drug Reactions is necessary and early referral of patients may be life saving.