{"title":"Genetic control of delayed type hypersensitivity to Mycobacterium leprae antigen.","authors":"N Ishii, H Nakajima, I Aoki, N Shimoda, T Mori","doi":"10.5025/hansen1977.59.154","DOIUrl":null,"url":null,"abstract":"<p><p>The mechanism of genetic control of Mycobacterium leprae-specific delayed type hypersensitivity (DTH) in mice was investigated in terms of footpad swelling response. Studies with various congenic and recombinant inbred strains of mouse revealed that M. leprae-specific DTH was controlled by genes within the I-A subregion. The footpad swelling response showed an antigen-specific pattern, revealing that M. leprae antigen was not cross-reactive with M. tuberculosis antigen. Treatment of immune lymphoid cells with monoclonal antibodies plus complement revealed that the cells responsible for DTH transfer were Lyt-2-, L3T4+ T cells. Suppressor T cell activity was not detected in low-responder mice.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"59 3-4","pages":"154-61"},"PeriodicalIF":0.0000,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nihon Rai Gakkai zasshi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5025/hansen1977.59.154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The mechanism of genetic control of Mycobacterium leprae-specific delayed type hypersensitivity (DTH) in mice was investigated in terms of footpad swelling response. Studies with various congenic and recombinant inbred strains of mouse revealed that M. leprae-specific DTH was controlled by genes within the I-A subregion. The footpad swelling response showed an antigen-specific pattern, revealing that M. leprae antigen was not cross-reactive with M. tuberculosis antigen. Treatment of immune lymphoid cells with monoclonal antibodies plus complement revealed that the cells responsible for DTH transfer were Lyt-2-, L3T4+ T cells. Suppressor T cell activity was not detected in low-responder mice.
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