An Innovative Framework for Integrative Rehabilitation in Dementia

V. Bragin, Ilya Bragin
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Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with multiple pathophysiological mechanisms affecting every organ and system in the body. Cerebral hypoperfusion, hypoxia, mitochondrial failure, abnormal protein deposition, multiple neurotransmitters and synaptic failures, white matter lesions, and inflammation, along with sensory-motor system dysfunctions, hypodynamia, sarcopenia, muscle spasticity, muscle hypoxia, digestive problems, weight loss, and immune system alterations. Rehabilitation of AD patients is an emerging concept aimed at achieving optimum levels of physical and psychological functioning in the presence of aging, neurodegenerative processes, and progression of chronic medical illnesses. We hypothesize that the simultaneous implementation of multiple rehabilitation modalities can delay the progression of mild into moderate dementia. This chapter highlights recent research related to a novel treatment model aimed at modifying the natural course of AD and delaying cognitive decline for medically ill community-dwelling patients with dementia. For practical implementation of rehabilitation in AD, the standardized treatment protocols are warranted.
痴呆综合康复的创新框架
阿尔茨海默病(AD)是一种进行性神经退行性疾病,具有多种病理生理机制,影响身体的各个器官和系统。脑灌注不足、缺氧、线粒体衰竭、异常蛋白沉积、多种神经递质和突触衰竭、白质病变和炎症,以及感觉运动系统功能障碍、动力不足、肌肉减少症、肌肉痉挛、肌肉缺氧、消化问题、体重减轻和免疫系统改变。阿尔茨海默病患者的康复是一个新兴的概念,目的是在衰老、神经退行性过程和慢性疾病进展的情况下实现最佳的生理和心理功能水平。我们假设同时实施多种康复方式可以延缓轻度痴呆向中度痴呆的进展。本章重点介绍了最近有关一种新的治疗模式的研究,该模式旨在改变老年痴呆症的自然病程,延缓社区患病痴呆症患者的认知能力下降。在AD康复的实际实施中,标准化的治疗方案是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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