[Hyperhaplotypes of A, B and DR loci of HLA region in patients with recurrent aphthous ulceration].

Abstract

Recurrent aphthous ulceration is a common disease affecting 10% of the general population. It is speculated that there is a genetic predisposition for the disease and for this reason HLA antigens may be involved. In our research we investigated 103 Greek patients suffering from recurrent aphthous ulcers (RAU) ranging in age from 13 to 60 years. For controls 242 individuals were tested the same period with no medical history of RAU. In our results we found that haplotype A2B12DR5 was statistically significantly increased in patients (p less than 0.05) thus considering this haplotype as a genetic marker for the disease in Greek patients.