Covid19 the Virus Immunology and Blood Coagulation, a Positive Feedback Cycle with Resultant Pathogenesis: A Perspective

Abstract

Covid 19 is a new beta corona virus which is driving the present pandemic across the world. The virus is highly transmissible through respiratory route with a Ro value varying between1.3-2.0. The virus is a direct strand RNA virus and is one of the largest viruses of RNA virus group. It has 11 open reading frame of which ORF 9-11 is involved in translation of structural S (Spike), E (Envelop), M (Matrix) and N (Nucleocapsid) glycoproteins. Of these S protein is very important from the point of view of virus engagement with the host cell and its infectivity.