Toxic effect of dieldrin on gonadotrophin levels (FSH and LH) in serum of mature female albino rats.

Abstract

Occurrence of hormonal disorders in 32 mature female albino rats fed on a 2 ppm of dieldrin for 3 weeks prompted a study into the effect of the insecticide on hormonal and histopathological changes in rat. FSH levels were significantly decreased in the 1st and 2nd weeks of the experiment, before they returned nearly to normal in the 3rd week. But LH levels, however, were significantly decreased only in the 1st week and slightly increased in the 2nd and 3rd weeks. Histopathological changes revealed severe haemorrhagic spots in the submucosal areas of the uterine wall, in addition to lymphocytic infiltration in the Graafian follicles due to direct effect of dieldrin on the genital tract of the rats.