Eating behavior and allelic variants of the leptin receptor gene in patients with type 2 diabetes: single center cross-sectional study

Sechenov Medical Journal Pub Date : 2023-05-16 DOI:10.47093/2218-7332.2023.14.1.15-26

D. Avzaletdinova, O. Kochetova, A. Z. Bulgakova, T. V. Morugova

{"title":"Eating behavior and allelic variants of the leptin receptor gene in patients with type 2 diabetes: single center cross-sectional study","authors":"D. Avzaletdinova, O. Kochetova, A. Z. Bulgakova, T. V. Morugova","doi":"10.47093/2218-7332.2023.14.1.15-26","DOIUrl":null,"url":null,"abstract":" Aim. The aim of this study was to analyze eating behavior and leptin receptor (LEPR) gene in patients with type 2 diabetes mellitus (T2D). Materials and methods. 83 patients with T2D (62 women, 21 men) aged 59.0 ± 9.9 years and 134 people without clinical and laboratory signs of diabetes mellitus (105 women, 29 men) aged 55.0 ± 10.2 years were examined. Bulimia nervosa was excluded in all the patients. Eating behavior was assessed using Dutch Eating Behavior Questionnaire, V.A. Losenkov’sImpulsivity Questionnaire. Genotyping of the LEPR gene rs1137100 marker was performed using polymerase chain reaction. The Mann-Whitney U-test and Pearson chi-square were used to compare the values of the variables; ROC-analysis was performed. Results. The emotional eating was more pronounced in T2D group (4.9 (4.1; 5.2) vs 3.1 (2.8; 3.8), p < 0.0001), but the restrained (2.8 (2.6; 3.6) vs 3.3 (2.6; 4.2), p < 0.0001) and external eating was less pronounced (3.3 (3.0; 3.8) vs 3.8 (3.3; 4.4), p < 0.0001), T2D patients were also less impulsive (47 (38; 66) vs 61 (54.5; 70), p < 0.0001). These differences for emotional eating are confirmed in both subgroup of excess body weight and in subgroups of all degrees of obesity. The best predictive model of T2D was obtained for emotional eating with a cut-off point 4.1 scores: sensitivity 74.7 %, specificity 79.1 %, AUROC = 0.777; 95 % confidence interval: 0.715–0.830, p < 0.0001. The distribution of genotypes by the polymorphic marker rs1137100 of the LEPR gene was similar in both groups. Restrictive eating was lower in patients with GG genotype compared to AA and GA (1.77 ± 0.52 vs 2.94 ± 0.08, p < 0.01). Conclusion. Рatients with T2D are characterized by emotional eating behavior. The association of the polymorphic locus rs1137100 of the LEPR gene with restrained eating behavior in T2D suggests the presence of genetic factors for the formation of eating patterns.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sechenov Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47093/2218-7332.2023.14.1.15-26","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Aim. The aim of this study was to analyze eating behavior and leptin receptor (LEPR) gene in patients with type 2 diabetes mellitus (T2D). Materials and methods. 83 patients with T2D (62 women, 21 men) aged 59.0 ± 9.9 years and 134 people without clinical and laboratory signs of diabetes mellitus (105 women, 29 men) aged 55.0 ± 10.2 years were examined. Bulimia nervosa was excluded in all the patients. Eating behavior was assessed using Dutch Eating Behavior Questionnaire, V.A. Losenkov’sImpulsivity Questionnaire. Genotyping of the LEPR gene rs1137100 marker was performed using polymerase chain reaction. The Mann-Whitney U-test and Pearson chi-square were used to compare the values of the variables; ROC-analysis was performed. Results. The emotional eating was more pronounced in T2D group (4.9 (4.1; 5.2) vs 3.1 (2.8; 3.8), p < 0.0001), but the restrained (2.8 (2.6; 3.6) vs 3.3 (2.6; 4.2), p < 0.0001) and external eating was less pronounced (3.3 (3.0; 3.8) vs 3.8 (3.3; 4.4), p < 0.0001), T2D patients were also less impulsive (47 (38; 66) vs 61 (54.5; 70), p < 0.0001). These differences for emotional eating are confirmed in both subgroup of excess body weight and in subgroups of all degrees of obesity. The best predictive model of T2D was obtained for emotional eating with a cut-off point 4.1 scores: sensitivity 74.7 %, specificity 79.1 %, AUROC = 0.777; 95 % confidence interval: 0.715–0.830, p < 0.0001. The distribution of genotypes by the polymorphic marker rs1137100 of the LEPR gene was similar in both groups. Restrictive eating was lower in patients with GG genotype compared to AA and GA (1.77 ± 0.52 vs 2.94 ± 0.08, p < 0.01). Conclusion. Рatients with T2D are characterized by emotional eating behavior. The association of the polymorphic locus rs1137100 of the LEPR gene with restrained eating behavior in T2D suggests the presence of genetic factors for the formation of eating patterns.

查看原文本刊更多论文

2型糖尿病患者的饮食行为和瘦素受体基因的等位变异:单中心横断面研究

的目标。本研究的目的是分析2型糖尿病(T2D)患者的饮食行为和瘦素受体(LEPR)基因。材料和方法。83例t2dm患者(女62例，男21例)，年龄59.0±9.9岁;134例无糖尿病临床及实验室体征者(女105例，男29例)，年龄55.0±10.2岁。所有患者均排除神经性贪食。采用荷兰饮食行为问卷、V.A. Losenkov冲动性问卷对饮食行为进行评估。采用聚合酶链反应对LEPR基因rs1137100标记进行基因分型。采用Mann-Whitney u检验和Pearson卡方检验比较变量的值;进行roc分析。结果。情绪化进食在T2D组更为明显(4.9 (4.1;5.2 vs 3.1 (2.8;3.8)， p < 0.0001)，但抑制(2.8)(2.6;3.6) vs 3.3 (2.6;4.2)， p < 0.0001)，外食不太明显(3.3 (3.0;3.8 vs 3.8 (3.3;4.4)， p < 0.0001)， T2D患者冲动程度也较低(47 (38;66) vs 61 (54.5;70)， p < 0.0001)。情绪化饮食的这些差异在超重亚组和所有程度的肥胖亚组中都得到了证实。情绪性进食的最佳预测模型为T2D，分值4.1分:敏感性74.7%，特异性79.1%，AUROC = 0.777;95%置信区间:0.715-0.830,p < 0.0001。两组LEPR基因多态性标记rs1137100基因型分布相似。GG基因型患者限制性饮食低于AA和GA(1.77±0.52 vs 2.94±0.08,p < 0.01)。结论。Рatients患有T2D的患者都有情绪性饮食行为。LEPR基因的多态性位点rs1137100与T2D中克制饮食行为的关联表明存在遗传因素影响饮食模式的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Sechenov Medical Journal

CiteScore

0.70

自引率

0.00%

发文量