EFFECT OF SELENIUM AND N-(P-AMYLCINNAMOYL) ANTHRANILIC ACID ON DOXORUBICIN-INDUCED KIDNEY INJURY IN RATS

İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi Pub Date : 2022-12-16 DOI:10.33715/inonusaglik.1174849

Kenan Yıldızhan, Zübeyir Huyut, F. Altındağ, Bünyamin Uçar

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Abstract

Doxorubicin (DOXR) is an important antitumor drug. However, the clinical use of DOXR has been limited due to serious undesirable side effects in many organs. This study aimed to analyse the effect of Selenium (Se) and N-(p-Amylcinnamoyl) Anthranilic Acid (ACA) on kidney tissue in DOXR, DOXR+Se, DOXR+Se+ACA. At the end of the study, the rat’s intracardiac blood and kidney tissues were removed under anaesthesia. Urea and creatinine levels were examined in serum samples taken from rats. In addition, histopathological examination and 8-OHdG expression in kidney tissue were determined by immunohistochemical analysis. After Se and ACA treatments, DOXR, glomerular atrophy, dilatation in tubular and glomerular, congestion in vessels, and vocalization in tubular epithelial cells were improved to varying degrees in the treatment groups with Se and ACA. In addition, Se and ACA treatments reduced the increasing expression of 8-OHdG caused by DOXR (p< 0.05). These findings indicated that Se and ACA might be used as important therapeutic agents to inhibit renal dysfunction and oxidative DNA damage after DOXR-induced kidney injury.

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硒和n -(对氨基肉桂酰)邻氨基苯酸对阿霉素所致大鼠肾损伤的影响

阿霉素(DOXR)是一种重要的抗肿瘤药物。然而，由于在许多器官中存在严重的不良副作用，DOXR的临床应用受到限制。本研究旨在分析硒(Se)和N-(对氨基肉桂酰)邻氨基苯甲酸(ACA)对DOXR、DOXR+Se、DOXR+Se+ACA组肾脏组织的影响。在研究结束时，在麻醉下取出大鼠的心内血液和肾脏组织。测定大鼠血清中尿素和肌酐水平。免疫组化法检测大鼠肾组织8-OHdG表达及组织病理学变化。硒和ACA处理后，硒和ACA处理组DOXR、肾小球萎缩、小管和肾小球扩张、血管充血、小管上皮细胞发声均有不同程度的改善。硒和ACA处理降低了DOXR引起的8-OHdG表达升高(p< 0.05)。提示硒和ACA可作为抑制doxr所致肾损伤后肾功能障碍和DNA氧化损伤的重要治疗药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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