Application of Gut Microbiomes in The Diagnosis and Treatment of Cancer

Abstract

In this study, the gut microbiome was closely related to human health. Changes in intestinal microbial composition promoted carcinogenesis and cancer development. Specific intestinal microorganisms and their metabolites regulated host physiological functions and tumor microenvironment and significantly affected the anti-tumor treatment response and its adverse effects. Gut microbiome-based strategies have shown promising prospects in the diagnosis and treatment of cancer, and many novel intestinal microbiological manipulation strategies have emerged. At the same time, there were many challenges in transforming intestinal microecology research into clinical practice. Key words: Gut microbiome; tumor microbiome; tumor microenvironment; immunotherapy.