Study of Serum Lipid Profile and Aminotransferases (ALT and AST) in Non-obese, Non-diabetic Nonalcoholic Fatty Liver Disease

Journal of Rangpur Medical College Pub Date : 2022-11-03 DOI:10.3329/jrpmc.v7i2.62643

Asm Mazedul Islam, M. Muttalib, Md Nazrul Islam, M. Haque, Mohammad Rafiqul Hoque, -. Maknunnahar

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引用次数: 1

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver diseases characterized by simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. It is the most common cause of cryptogenic cirrhosis. NAFLD is associated with obesity, insulin resistance, hypertension, type 2 diabetes mellitus, and dyslipidemia. Objective: The study aimed to assess the changes in lipid profile and aminotransferases (ALT and AST) in Non-alcoholic fatty liver disease (NAFLD). Methods: This observational cross-sectional study was carried out in the department of Biochemistry, Mymensingh Medical College in cooperation with the Centre for Nuclear Medicine and Ultrasound, Mymensingh from January 2012 to June 2013 after the approval of the protocol. A total of 120 subjects were included through purposive sampling, among them, 60 subjects were with fatty liver disease (group-I) and another 60 were without fatty liver (group-II) with ultrasonography. The sampling method was purposive (non-random). Relevant laboratory investigations were performed by using established methods to achieve the objectives. Results: The majority of the subjects with NAFLD (33.33%) were in 51-60 years (in Group-I). Mean serum total cholesterol, triacylglycerol, LDL-cholesterol, and HDL-cholesterol were 203.33±21.83, 184.41±33.31, 126.28±18.75, and 40.17±6.32 mg/dl in group-I and 167.65±9.83, 128.77±11.65, 101.74±9.29 and 40.16±3.55 mg/dl in group-II respectively. Significant differences were found in the case of total cholesterol (p<0.001), triacylglycerol (p<0.001), and LDL-cholesterol (<0.001), but no significant difference was found in the case of HDL-cholesterol (p>0.05). Serum ALT and AST were 49.43±16.98, 45.20±13.56 U/L in group-I and 32.83±4.54, 28.68±4.31 U/L in the group- II respectively. Significant differences were found in case of ALT (p <0.001) and AST (p <0.001). Conclusion: Nonalcoholic fatty liver disease is associated with dyslipidemia and with the elevation of serum ALT and AST. J Rang Med Col. September 2022; Vol. 7, No. 2:35-39

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非肥胖、非糖尿病、非酒精性脂肪肝患者血脂及转氨酶(ALT和AST)的研究

背景:非酒精性脂肪性肝病(NAFLD)包括一系列以单纯脂肪变性到非酒精性脂肪性肝炎(NASH)、纤维化和肝硬化为特征的肝脏疾病。它是隐源性肝硬化最常见的原因。NAFLD与肥胖、胰岛素抵抗、高血压、2型糖尿病和血脂异常有关。目的:本研究旨在评估非酒精性脂肪性肝病(NAFLD)患者血脂和转氨酶(ALT和AST)的变化。方法:本观察性横断面研究在方案批准后，于2012年1月至2013年6月在Mymensingh医学院生物化学系与Mymensingh核医学与超声中心合作进行。通过目的抽样共纳入120例受试者，其中超声检查有脂肪肝60例(ⅰ组)，无脂肪肝60例(ⅱ组)。抽样方法是有目的的(非随机的)。采用既定方法进行相关实验室调查，以达到目的。结果:NAFLD患者以51 ~ 60岁(33.33%)居多(ⅰ组)。ⅰ组平均血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇分别为203.33±21.83、184.41±33.31、126.28±18.75、40.17±6.32 mg/dl;ⅱ组平均血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇分别为167.65±9.83、128.77±11.65、101.74±9.29、40.16±3.55 mg/dl。总胆固醇组差异有统计学意义(p0.05)。ⅰ组血清ALT、AST分别为49.43±16.98、45.20±13.56 U/L，ⅱ组为32.83±4.54、28.68±4.31 U/L。ALT (p <0.001)和AST (p <0.001)差异有统计学意义。结论:非酒精性脂肪性肝病与血脂异常及血清ALT和AST升高有关。第七卷2:35-39

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Journal of Rangpur Medical College

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