RBC flow imaging and pO/sub 2/ measurement in cerebral microcirculation:effect of hemodilution on oxygen supply to brain cortical arterioles

Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439) Pub Date : 2003-12-01 DOI:10.1109/IEMBS.2003.1279426

T. Arai, K. Tsukada, E. Sekizuka, C. Oshio, S. Terao, K. Hase, H. Minamitani

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Abstract

Hemodilution is still one of the taken therapy in stroke due to increase in cardiac output and decrease in blood viscosity. However, it is not clear the effect of a decrease in oxygen carrying capacity on oxygen supplying to the brain. The aim of this study is to seek the effect of isovolemic hemodilution on oxygen supply. We observed RBC flow rate and oxygen tension pO/sub 2/ on brain cortical arterioles by using closed cranial window, high-speed videomicroscopy and oxygen dependent quenching of phosphorescence technique. The result showed that RBC flow rate increased about four times from base line and pO2 values were kept within a arteliolar biological state (about a range from 70 to 90mmHg) until Hb was about l0g/dl, respectively. And more severe hemodilution made the both values decrease acutely. The results suggest the increase of RBC flow caused by isovolemic hemodilution keeps supplying oxygen to the brain cortex as low as Hb is l0g/dl.

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脑微循环红细胞血流成像及pO/ sub2 /测定:血液稀释对脑皮质小动脉供氧的影响

由于心排血量增加和血液粘度降低，血液稀释仍然是中风治疗的一种方法。然而，携带氧气能力的下降对大脑供氧的影响尚不清楚。本研究旨在探讨等容血稀释对供氧的影响。采用封闭颅窗、高速视频显微镜和氧依赖猝灭磷光技术观察脑皮质小动脉红细胞流速和氧张力pO/sub 2/。结果表明，红细胞流速比基线增加了约4倍，pO2值保持在动脉生物学状态(约在70 ~ 90mmHg范围内)，直到Hb分别约为10g /dl。血液稀释程度越严重，两者均急剧下降。结果表明，等容血液稀释引起的红细胞流量增加使脑皮质供氧保持在低至Hb为10g /dl。

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Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)

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