Evidencias clínicas del uso de moduladores de la microbiota intestinal para el tratamiento de trastornos mentales: una revisión bibliográfica sistemática
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引用次数: 0
Abstract
There is an association between intestinal dysbiosis, the gut–brain axis and mental health. PubMed, Embase and Web of Science were searched for analysing clinical trials in which microbiota modulators are used in mental health disorders for this systematic review. An evaluation of each study was made using CONSORT and only eight articles were suitable for this analysis: five were in depressive patients, and only one corresponded to either schizophrenia, attention-deficit/hyperactivity disorder or Alzheimer's disease. It is possible to conclude that microbiota modulators might be effective coadjuvants in traditional antidepressant or antipsychotic drugs treatment. However, the heterogeneity of interventions, small sample size, lack of intestinal microbiota assessment and symptoms auto report should be addressed before a conclusion can be made. PROSPERO registration number: CRD42020202938.
肠道生态失调、肠脑轴和心理健康之间存在关联。本系统综述检索了PubMed、Embase和Web of Science，以分析微生物群调节剂用于精神健康障碍的临床试验。使用CONSORT对每项研究进行了评估，只有8篇文章适合这一分析:5篇是抑郁症患者，只有1篇与精神分裂症、注意力缺陷/多动障碍或阿尔茨海默病相关。这有可能得出结论，微生物群调节剂可能是传统抗抑郁或抗精神病药物治疗的有效辅助剂。然而，在得出结论之前，应解决干预措施的异质性，样本量小，缺乏肠道微生物群评估和症状自动报告等问题。普洛斯彼罗注册号:CRD42020202938。
期刊介绍：
Es la Publicación Oficial de la Sociedad Española de Psiquiatría Biológica. Los recientes avances en el conocimiento de la bioquímica y de la fisiología cerebrales y el progreso en general en el campo de las neurociencias han abierto el camino al desarrollo de la psiquiatría biológica, fundada sobre bases anatomofisiológicas, más sólidas y científicas que la psiquiatría tradicional.
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