Formulation and Evaluation of Anticancer Drug (Tamoxifen) Loaded Nanosponges

B. Narender, P. Sridhar
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引用次数: 3

Abstract

The purpose of this research was to prepare Tamoxifen loaded Nanosponge gel for Sustained release of drug, increase the drug solubility, and increase the drug permeability, to reduce the dosing frequency and side effects. The FTIR studies proved that there were no interactions between the drug and Polymers. Homogenization technique followed by centrifugation was employed to prepare Nanosponge using various polymers. The formulation were prepared using different Polymers (hydroxy Ethyl cellulose and PVA) in different ratios (Drug: Polymer–1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:3.5, 1:4 and 1:4.5) Using dichloromethane as cross linker as well as solvent. The formulations were characterized for drug entrapment efficiency. The Drug content of the formulations was observed to be from 62.90 to 95.94. The entrapment efficiency was found to be 68.97 to 99.44. The highest entrapment efficiency was observed with 98.68 and 99.44 for the formulations F4 and F8. The particle size analysis done by Malvern Zeta sizer showed that the average particle size of Tamoxifen loaded Nanosponge F3 average particle size of Tamoxifen loaded Nanosponge is 91.34nm and the poly dispersity index was found to be 0.196 and F8 average particle size of Tamoxifen Nanosponge F7 was 201.34nm and the poly dispersity index was found to be0.178. The in-vitro release of Tamoxifen Nanosponge optimized formulation F4 was found to be 46.39 % and F8was 45.56 % at the end of 24 hours. The drug content of the Gel G1and G2 was found to be 84 % and 81 % respectively. The in-vitro release of Doxorubicin Nanosponge Gel formulation G1 was found to be 28.77% and G2 was 22.12 % at the end of 24hours. The pH of the gels G1 and G2 was found to be 4.98 and 4.82 respectively. The Viscosity of the gels G1 and G2 was found to be 2.839x10 cps and 2.823x10 cps respectively. Both of the optimized formulations of the respected drugs followed first order release kinetics with hi-guchi mechanism. In-vivo test performed showed that the both the formulations of respected drugs able to retain the drug for prolonged periods of time to provide stable drug release and bioavailability
载抗癌药物他莫昔芬纳米海绵的制备及评价
本研究的目的是制备负载他莫昔芬的纳米海绵缓释凝胶,提高药物的溶解度,增加药物的渗透性,以减少给药频率和副作用。FTIR研究证明,该药物与聚合物之间没有相互作用。采用均质离心法制备了不同聚合物的纳米海绵。以二氯甲烷为交联剂和溶剂,以不同的聚合物(羟基乙基纤维素和PVA)按不同的比例(药物:聚合物- 1:1、1:1.5、1:2、1:2.5、1:3、1:3.5、1:4和1:4.5)制备了该配方。对配方进行了药物包封效率表征。制剂的药物含量在62.90 ~ 95.94之间。捕集效率为68.97 ~ 99.44。F4和F8的捕集率最高,分别为98.68和99.44。Malvern Zeta粒度分析表明,负载他莫昔芬的纳米海绵F3的平均粒径为91.34nm,聚分散指数为0.196;负载他莫昔芬的纳米海绵F7的平均粒径为201.34nm,聚分散指数为0.178。24 h时,他莫昔芬纳米海绵优化配方F4的体外释放度为46.39%,f8为45.56%。凝胶g1和G2的药物含量分别为84%和81%。24h时,阿霉素纳米海绵凝胶制剂G1的体外释放量为28.77%,G2的体外释放量为22.12%。凝胶G1和G2的pH分别为4.98和4.82。凝胶G1和G2的粘度分别为2.839x10 cps和2.823x10 cps。两种药物的优化配方均符合一级释放动力学,具有hi-guchi机制。体内试验表明,这两种制剂均能使药物保持较长时间,从而提供稳定的药物释放和生物利用度
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