Study on Rapid Optical Measurement Method and Device of Hemoglobin Concentration

2023 IEEE 6th Information Technology,Networking,Electronic and Automation Control Conference (ITNEC) Pub Date : 2023-02-24 DOI:10.1109/ITNEC56291.2023.10082378

Hangrui Yan, Zhiyong Xiong, Guiyang Yang, Shaokun Li

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Abstract

In order to achieve rapid and accurate measurement of hemoglobin concentration in human whole blood, a rapid optical detection system was developed. The measurement principle, optical path design, mechanical structure design and microcuvette design are studied. Firstly, the rapid measurement of hemoglobin concentration was studied by using the scattering and spectral absorption characteristics of erythrocytes. Secondly, the optical path design and structure design of the optical measurement system are analyzed and studied. Then, a microcuvette for optical detection is designed, and its structure is designed according to fluid mechanics, and its precision is analyzed according to measurement error. Finally, the calibration curve and precision analysis of the measurement system, as well as the correlation analysis with the standard High iron cyanide process method are given. The experimental results show that the system can give the hemoglobin concentration results within 3 seconds, the CV value is less than 2%, the correlation coefficient is greater than 0.99, and the correlation with the international standard cyanidation high-speed iron method can reach more than 0.99.The detection device has the characteristics of high speed, high precision, no pollution in the detection process, and high efficiency and environmental protection.

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血红蛋白浓度快速光学测量方法及装置的研究

为了实现人体全血血红蛋白浓度的快速、准确测量，研制了一种快速光学检测系统。研究了测量原理、光路设计、机械结构设计和微比皿设计。首先，利用红细胞的散射和光谱吸收特性，研究了快速测定血红蛋白浓度的方法。其次，对光学测量系统的光路设计和结构设计进行了分析和研究。然后，设计了一种用于光学检测的微比色皿，根据流体力学原理对其结构进行了设计，并根据测量误差对其精度进行了分析。最后给出了测量系统的校准曲线和精度分析，并与标准的高氰化铁工艺方法进行了相关性分析。实验结果表明，该系统能在3秒内给出血红蛋白浓度结果，CV值小于2%，相关系数大于0.99，与国际标准氰化高速铁法的相关性可达0.99以上。该检测装置具有速度快、精度高、检测过程中无污染、高效环保等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

2023 IEEE 6th Information Technology,Networking,Electronic and Automation Control Conference (ITNEC)

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