A Digital Olfactometer for Smell Threshold Measurements in Neurodegenerative Disease Diagnostics

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI:10.1109/EMBSW.2007.4454170

D. Hayes, D. Wallace, D. Taylor, B. Antohe, I. Achiriloaie, N. Comparini

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引用次数: 3

Abstract

Ink-jet microdispensing technology was used to develop an instrument for the quantitative determination of the olfactory threshold. An electrical pulse applied to the piezoelectric microdispenser causes a drop of fluid to be ejected through a precise orifice. An electronic console actuates the piezoelectric dispensing elements and controls the number of drops that are dispensed and evaporated to create a fragrance cloud. The number of drops that are generated, evaporated and presented to the patient's nose for detection is adjusted according to a preset algorithm until the patient's smell threshold is discovered. Neurodegenerative disease patients tested with the developed olfactometer showed a significant elevation of their olfactory threshold as compared to normal controls. This result agrees with literature studies that indicate the sense of smell is one of the first affected by neurodegenerative disease. Through its precise control and detection capability, the digital olfactometer described in this paper can be used as an early screening tool for neurodegenerative diseases through olfactory threshold determination.

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用于神经退行性疾病诊断嗅觉阈值测量的数字嗅觉计

采用喷墨微点胶技术，研制了一种嗅阈值定量测定仪器。施加在压电微分配器上的电脉冲使一滴液体通过一个精确的孔喷射出来。电子控制台驱动压电点胶元件，并控制滴胶和蒸发的数量，以形成香味云。根据预设的算法，生成、蒸发并呈现给患者鼻子供检测的液滴的数量会进行调整，直到发现患者的气味阈值。神经退行性疾病患者用开发的嗅觉计测试显示，与正常对照相比，他们的嗅觉阈值显着升高。这一结果与文献研究一致，表明嗅觉是最先受到神经退行性疾病影响的感官之一。通过其精确的控制和检测能力，本文描述的数字嗅觉仪可以通过嗅觉阈值测定作为神经退行性疾病的早期筛查工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2007 IEEE Dallas Engineering in Medicine and Biology Workshop

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